Extrusion-based additive manufacturing of Mg-Zn alloy scaffolds

Porous biodegradable Mg and its alloys are considered to have a great potential serve as ideal bone substitutes. The recent progress in additive manufacturing (AM) has prompted application fabricate scaffolds with geometrically ordered porous structures. Extrusion-based AM, followed by debinding sintering, been recently demonstrated powerful approach fabricating such scaffolds, which can avoid some crucial problems encountered when applying powder bed fusion AM techniques. However, pure exhibit too high rate of vitro biodegradation. In the present research, alloying through pre-alloyed Mg-Zn was ultilized enhance corrosion resistance mechanical properties simultaneously. biodegradation behavior, properties, electrochemical response fabricated were evaluated. Moreover, preosteoblasts these systematically evaluated compared their scaffolds. porosity 50.3% strut density 93.1% composed matrix MgZn2 second phase particles. decreased 81% at day 1, Over 28 days static immersion modified simulated body fluid, from 2.3 ± 0.9 mm/y 0.7 0.1 mm/y. yield strength Young's modulus about 3 times those remained within range trabecular throughout tests. Indirect culture MC3T3-E1 extracts indicated favorable cytocompatibility. direct cell culture, cells could spread form filopodia on surface Overall, this study demonstrates extrusion-based be further developed bone-substituting biomaterials.